A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span.In C.elegans, bile acid-like steroids called equi-jec 6 the dafachronic acids (DAs) regulate developmental timing and longevity through the conserved nuclear hormone receptor DAF-12, a homolog of mammalian sterol-regu